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. 2017 May 8;7:1525. doi: 10.1038/s41598-017-01743-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DNMT1-isoform1 fails to localize in mitochondria and exclusively localizes to the nucleus at all the analyzed time points. (Ai-Bi) Schematic diagram depicting the structure of: (Ai) DNMT1-iso1; (Bi) DNMT1-iso1 with uORF. (Aii-Bii) Representative confocal images of H1299 cells showing localization pattern of exogenously overexpressed: (Aii) DNMT1-isoform1 and (Bii) DNMT1-iso1 with uORF at four different time points (24, 48, 72, 96 hrs). (C) Pearson co-localization coefficient for mitochondrial localization of DNMT1-iso1 and DNMT1-iso1 with uORF.