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. 2017 May 8;7:1525. doi: 10.1038/s41598-017-01743-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overexpression of DNMT1-isoform3 causes hypermethylation of mitochondrial DNA. Representative confocal images of H1299 cells stably overexpressing DNMT1-iso3; (A) DNMT1 localisation pattern; (B) 5 mC staining; (C) % of 5 mC at defined CpG sites of mitochondrial genome resulting from overexpression of DNMT1-iso3; (D) Relative fold enrichment of selected mitochondrial regions for DNMT1-isoform3 binding by CHIP analysis.