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. 2017 May 8;7:1525. doi: 10.1038/s41598-017-01743-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Exogenous overexpression of DNMT1-isoform3 affects mitochondrial biology. Representative screen shots and bar diagram for relative: (A) mitochondrial membrane potential; (B) mitochondrial mass; (C) mitochondrial activity; (D) ATP levels on exogenous overexpression of DNMT1-isoform3 in H1299 cells. (E) The real time and Western profile of DNMT1-iso3 overexpressing cells. (F) Semi-quantitative gene expression profile and (G) Western blot scans of selected mtDNA encoded and nuclear genome encoded mt genes in overexpressing DNMT1-iso3 H1299 cells. Relative fold of expression of the analyzed protein was calculated by densitometry analysis on normalization with respective β-actin expression and indicated (in values) just below the scans. The western blot scans were cropped for presentation in the main figure, the original scans are provided in the supplementary information.