Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 May 8;7:1525. doi: 10.1038/s41598-017-01743-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Mitochondrial DNA is hypomethylated under various conditions of nutritional and oxidative stress. (A) Relative mitochondrial activity in H1299 cells under different conditions of (i) nutritional and (ii) oxidative stress. (B) Western Blot scans of DNMT1 isoforms expression profile under (i) nutritional and oxidative (ii) stress conditions. (C) % of 5 mC at certain defined CpG sites of mitochondrial genome resulting from nutritional (i) and oxidative stress (ii) conditions respectively. SD, SRF and GF stands for serum deprivation, serum re-fed and glucose starvation respectively. H₂O₂ and CoCl₂ treated and non-treated are indicated with (+) and (−) sign respectively. Relative fold of expression of DNMT1-isoform3 is calculated by densitometry analysis on normalization with respective β-actin expression and indicated (in values) just below the DNMT1 scans.