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. 2017 May 8;7:1539. doi: 10.1038/s41598-017-01826-w

Figure 6.

Figure 6

Inhibition of GSK3β results in recovery of electrophysiology 24 hours following NMDA-induced injury. (A) Representative traces of sEPSCs recorded from rat cortical neurons treated with < 0.1% DMSO (control; n = 16), 1 µM AS1842856 (n = 16), 10 mM LiCl (n = 10). (B,C) Bar graph analysis of sEPSC frequency and amplitude following 4 hour baseline drug treatment and 24 hour recovery period. (D) Representative traces of sEPSCs recorded from rat cortical neurons treated with < 0.1% DMSO (control; n = 29), 20 µM NMDA (n = 14), AS1842856 + NMDA (n = 9), LiCl + NMDA (n = 27). (E,F) Bar graph analysis of sEPSC frequency and amplitude following 4 hour drug treatment, 5 minute 20 µM NMDA-induced injury, and 24 hour recovery period. *p < 0.05, **p < 0.01 determined by one-way ANOVA followed by Tukey-Kramer multiple comparisons test. Error bars indicate ± SEM.