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. 2017 May 8;7:1578. doi: 10.1038/s41598-017-01822-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Selected TKIs inhibit bacterial cell wall-mediated lipolysis in adipocytes. Relative levels of glycerol released from 3T3-L1 adipocytes after stimulation with the Nod1 ligand FK565 (10 μg/mL) for 48 h and pre-incubated for 1 h with 1, 5 or 10 μM of various TKIs (A) n = 6–69. Rate of glycerol release over 48 h in 3T3-L1 adipocytes pre-incubated for 1 h with 0.2, 1 or 5 μM gefitinib, SB203580, and imatinib (B) n = 8–49. Rate of glycerol release over 48 h in 3T3-L1 adipocytes pre-incubated for 1 h with PIA (1 or 10 μM) and stimulated with FK565 (10 μg/mL), or pre-incubated with gefitinib (1 or 5 μM) and stimulated with isoproterenol (2 μM) respectively (C) n = 6–10. Values are mean ± SEM. Conditions with different letters (a, b, c) denote a statistical difference compared to all other conditions without the same letter (P < 0.05). *Denotes partial inhibition that is statistically lower than FK565-stimulated glycerol release, but significantly higher than basal glycerol release for a given TKI (p < 0.05).