Table 4.

Multiple mutations driving 10 antigenic drifts for H3N2 influenza viruses inferred by JRFR.

Antigenic drift events	Combination of mutations
HK68-EN72	S193N-G144D
EN72-VI75	N53D-S193D-S145N
VI75-TX77	S137G
TX77-BK79	D144V-N2K
BK79-SI87	Y155H-K189R
SI87-BE89	N145K, N145K-G135E, N145K-N193S
BE89-BE92	K145N-E156K-R189S, K145N-E156K-T262N-R189S, K145N-E156K-S133D-R189S
BE92-WU95	K135T-N145K-L226V, K135T-N145K-N262S
WU95-SY97	V196A-N276K-E158K-K156Q, V196A-N276K-E158K-K156Q-K62E
SY97-FU02	A131T-H155T-V202I