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. 2017 Mar 6;13(5):3291–3298. doi: 10.3892/ol.2017.5808

Figure 4.

Figure 4.

Comparison of natural T cells and NK cells in PBMCs between patients with HCC and healthy donors and an altered CD4/CD8 distribution pattern in natural T cells and conventional T cells in tumorous tissues compared with non-tumorous tissues. (A) The percentages of natural T cells in PBMCs from patients with HCC (n=11) and from healthy donors (n=11). (B) The percentages of NK cells in PBMCs from patients with HCC (n=11) and in healthy donors (n=11). (C) The percentages of FOXP3+ cells in natural T cells (CD3+CD56+) and conventional T cells (CD3+CD56−) in PBMCs from individual patients (n=11). (D) An altered CD4/CD8 distribution pattern in natural T cells in tumor tissues compared with non-tumor tissues. (E) An altered CD4/CD8 distribution pattern in conventional T cells in tumorous tissues compared with non-tumorous tissues was observed. (F) An unaltered CD4/CD8 distribution pattern in natural T cells and T cells in PBMCs from patients with HCC compared with normal donors. *P<0.05, **P<0.01, ***P<0.001. PBMCs, peripheral blood mononuclear cells; HCC, hepatocellular carcinoma; CD, cluster of differentiation; HD, healthy donors; FOXP3, forkhead box P3; T, tumor; H, patients with HCC; N, normal donors.