Table 1.
Electrophysiological parameters (conduction velocity, APD80 and dV/dtma) measured in control and ChR2-expressing NRVM cultures.
| Conduction velocity (cm/s) | APD80 (ms) | dV/dtmax (V/s) | |
|---|---|---|---|
| Control cultures Electrical pacing (n = 8) | 19.3 ± 4.1 | 114.5 ± 29.8 | 32.3 ± 5.0 |
| ChR2-expressing Electrical pacing (n = 8) | 18.9 ± 1.0* (p = 0.44) | 124.7 ± 29.2* (p = 0.12) | 32.7 ± 2.9* (p = 0.87) |
| ChR2-expressing Optical pacing (n = 6) | 19.5 ± 1.4# (p = 0.557) | 133.8 ± 20.1# (p = 0.152) | 32.3 ± 6.5# (p = 0.387) |
Pacing frequency = 2 Hz, culture duration ranged from 6 to 8 days. *Non-significant vs. control cultures paced electrically (two-tailed unpaired Student’s t test). #Non-significant vs. ChR2-expressing cultures paced electrically (two-tailed unpaired Student’s t test).