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. 2017 May 8;7:1548. doi: 10.1038/s41598-017-01528-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Wound healing of skin defects in diabetic mice. (A) Representative photos of wound healing in full-thickness cutaneous ulcers (left) and quantification of wound-opening sizes at different time points (right) in db/db mice. The inner diameter of the splints was 14 mm; n = 4 ulcers; *p _day10 = 0.0245; *p _day14 = 0.021. (B) Mallory-Azan trichrome stain of wound-tissue samples harvested 24 days post surgery (upper). Collagen was stained blue. Wound pathohistology was evaluated via quantification of dermal collagen deposition (lower). The dashed line indicates the collagen-poor area in the dermis; n = 4 ulcers; five points were photographically measured in each sample; *p = 0.040, **p = 0.043. Scale bars = 200 µm. (C) Immunofluorescence of the adipose layer of the wound: viable adipocytes (perilipin, white), macrophages (mac-2, green), vasculature (vWF, red), and nuclei (blue). *Represents crown-like structures which are perilipin-negative round area (oil drops) surrounded by Mac-2-positive infiltrated macrophages. Scale bars = 100 µm.