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. 2017 May 8;7:1519. doi: 10.1038/s41598-017-01771-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Infection with LM-PLP generates PLP-specific CD8 T cells that are not pathogenic. Intracellular cytokine staining was performed using bulk splenocytes harvested from LM-PLP infected B6 mice on d7 post infection. Splenocytes were left unstimulated, or stimulated with either OVA257-264 (positive control) or PLP178-191. Representative flow plots show CD8 (A) and CD4 (B) T cell responses from LM-PLP-infected mice. Summary bar graphs display the frequency (C) and absolute numbers (D) of antigen-specific CD8 T cell responses to indicated antigens. (E) Mice were infected with either LM-OVA or LM-PLP and followed for neurologic signs of disease with or without pertussis toxin administration. Data are representative of at least three independent experiments in each panel with at least six mice per group per experiment. ***p < 0.001, ****p < 0.0001.