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. 2017 May 9;7:1632. doi: 10.1038/s41598-017-01756-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Model of ZIKV NS5-MTase_MS2042 with cap-0 RNA and comparison with the human mRNA cap methyltransferases CMTr1 and RNMT. (a) Qualitative electrostatic surface potential of ZIKV NS5-MTase_MS2042 with a cap-0(^N7MeGpppA_2′OH) RNA model derived from the structure of DENV3 NS5 (5DTO). (b) Magnified view of the model showing steric overlap of the cap-0 adenine and its 2′O atom with the 4-fluorophenyl group of MS2042. Comparison of loop β4-αD in (c) ZIKV NS5-MTase, (d) human nucleoside-2′-O methyltransferase (CMTr1, PDB id 4N49), and (e) human mRNA cap guanine-N7 methyltransferase (RNMT, PDB id 3EPP).