Table 1.

.

Ligand	K D (μM)	ΔG (Kcal mol−1)	ΔH (Kcal mol−1)	−TΔS (Kcal mol−1)	K D relative to that of SAM
SAM	2.58	−7.70	−32.6	24.9	—
SAH	2.87	−7.60	−39.8	32.2	1.11
MS2042	24.3	−6.30	−20.3	14.0	9.42

Thermodynamic binding parameters of SAM, SAH, and MS2042 to ZIKV NS5-MTase.