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. 2017 May 9;7:1613. doi: 10.1038/s41598-017-01559-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Second-generation DNAzymes derived from RNV143, targeting the ITGA4 mRNA. The activity of DNAzymes directly correlated with the percentage of ITGA4 mRNA knockdown. Activities of DNAzymes were calculated as described in Materials and Methods. The catalytic motifs are shown in red, the arm regions are in black and the residues modified with LNA are in blue. The sequences are from 5′ → 3′.

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