Table 1.

Findings of small-animal ultrasound in the 7 treatment groups and 4 comparison groups.

Treatment groups (n = 6)	Number (%) of recanalization* at each time point					PSV (cm/s) in left CCA at each time point
	After treatment					After irradiation	After treatment
	4 h	24 h	2 d	4 d	7 d		4 h	24 h	2 d	4 d	7 d
A. 0.45 mg/kg rt-PA bolus	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 ± 0	0 ± 0	0 ± 0	0 ± 0	0 ± 0	0 ± 0
B. 0.9 mg/kg rt-PA bolus (n = 8)	5 (63%)	5 (63%)	5 (63%)	6 (75%)	4 (50%)	0 ± 0	26 ± 31	58 ± 36	68 ± 50	58 ± 46	37 ± 55
C. Focus ultrasound (FUS)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 ± 0	0 ± 0	0 ± 0	0 ± 0	0 ± 0	0 ± 0
D. 2 g/kg BNG-1 per os for 7 days	0 (0%)	2 (33%)	2 (33%)	1 (17%)	1 (17%)	0 ± 0	11 ± 21	90 ± 7	97 ± 81	15 ± 30	0 ± 0
E. 0.45 mg/kg rt-PA bolus + 2 g/kg BNG-1	0 (0%)	1 (17%)	2 (33%)	3 (50%)	3 (50%)	0 ± 0	23 ± 40	83 ± 72	75 ± 65	83 ± 79	89 ± 87
F. 0.45 mg/kg rt-PA bolus + FUS (n = 8)	7 (88%)	7 (88%)	7 (88%)	5 (63%)	5 (63%)	0 ± 0	63 ± 28	55 ± 34	76 ± 39	83 ± 63	79 ± 102
G. 0.45 mg/kg rt-PA bolus + FUS + 2 g/kg BNG-1	5 (83%)	6 (100%)	6 (100%)	5 (83%)	6 (100%)	0 ± 0	60 ± 16	86 ± 49	101 ± 45	100 ± 38	97 ± 28
Comparison groups (n = 6)
H. 0.45 mg/kg rt-PA 20% bolus + 80% IV fusion + FUS	3 (50%)	5 (83%)	5 (83%)	5 (83%)	6 (100%)	0 ± 0	62 ± 56	62 ± 12	62 ± 40	57 ± 42	93 ± 31
I. 0.9 mg/kg rt-PA 10% bolus + 90% IV fusion	1 (17%)	5 (83%)	4 (67%)	6 (100%)	5 (83%)	0 ± 0	66 ± 38	84 ± 32	84 ± 37	89 ± 36	76 ± 55
J. 0.9 mg/kg rt-PA bolus + FUS	4 (67%)	4 (67%)	5 (83%)	5 (83%)	4 (67%)	0 ± 0	47 ± 66	54 ± 38	93 ± 66	89 ± 54	55 ± 78
K. 0.9 mg/kg rt-PA bolus + 2 g/kg BNG-1	4 (67%)	4 (67%)	5 (83%)	5 (83%)	5 (83%)	0 ± 0	55 ± 59	49 ± 46	66 ± 38	91 ± 33	88 ± 51

*Recanalization is defined as stenotic degree ≤50% after treatment. CCA = common carotid artery.