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. 2017 May 9;7:1630. doi: 10.1038/s41598-017-01915-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Excessive phosphorylation of EG5 induced by PP2A deficiency causes metaphase delay and segregation errors in anaphase. (A) Duration of metaphase in cells infected with lenti-virus (shcoo2, shPP2A/Cα-2), cells transfected with FLAG-tagged EG5, EG5 T926D and cells treated with Okadaic acid. (B) Duration of metaphase in HeLa cells overexpressing EG5T926D, or with PP2A/Cα knockdown, or with both over-expression of EG5 T926D and with PP2A/Cα knockdown. (C) A variety of mitotic errors occurred in HeLa cells (shcoo2, shPP2A/C-2, EG5, EG5/T926D, Okadaic acid) (N > 80).