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. 2017 May 11;7:1796. doi: 10.1038/s41598-017-01268-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum Shh and IL-6 significantly differ between normal and cancer patients. (A) Serum and plasma Shh and IL-6 levels from healthy volunteers, early operable and untreated progressive metastatic breast cancer patients. (B) Serum Shh and IL-6 levels from early operable patients before and after surgery, as well as before and after chemotherapy from untreated progressive metastatic patients. (C) ROC curves of serum Shh and IL-6 as predictors in progressive metastatic breast cancer patients.