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. 2017 May 11;7:1796. doi: 10.1038/s41598-017-01268-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Risk stratification based on EFS and OS correlates with serum Shh and IL-6 levels in metastatic breast cancer. (A) Event free survival (EFS) of all progressive metastatic patients by serum Shh levels, (B) EFS of all progressive metastatic patients based on serum IL-6 levels, (C) EFS of all progressive metastatic patients based on a two-factor model (serum Shh and IL-6). (D) Overall survival (OS) of all progressive metastatic patients based on a two-factor model (serum Shh and IL-6). Note worse overall outcome for patients with both Shh and IL-6 at a high level.