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. 2017 May 10;7:1646. doi: 10.1038/s41598-017-01602-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Comparison between rat and human Biliverdin Reductase (rBVRA and hBVRA) activity in the presence of 0, 15, 30 or 60 μM Montelukast or (B) 0, 15, 30 or 60 μM Disulfiram. The conversion of biliverdin to bilirubin was determined by measuring absorbance over a period of 60 minutes at wavelengths 453 nm (bilirubin) and 670 nm (biliverdin). Biliverdin reductase activity was determined by calculating the slope over the linear part of the reaction and is expressed as residual activity relative to the vehicle control 1% DMSO. Data represent the mean ± SD of the data obtained from three independent experiments (n = 3). Two-way analysis of variance (ANOVA) was used for statistical analysis, **p < 0.01, ***p < 0.001.