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. 2017 May 12;7:1876. doi: 10.1038/s41598-017-01963-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ZBP1 phosphorylation at Ser181 is needed for the proper dendritic arborization of hippocampal neurons. (a) Representative confocal images of cultured hippocampal neurons transfected on DIV8 for 2 days as indicated. Neuron morphology was visualized by co-transfection with mRFP. Scale bar = 50 µm. (b) Total number of dendritic tips (TNDT) of neurons transfected as in (a). The data are expressed as mean ± SEM. ***p < 0.001, compared with pSuper/pEGFP-C1-transfected cells; ^### p < 0.001, compared as indicated (Kruskal-Wallis test followed by Dunn’s post hoc test). Cell images were obtained from two independent culture batches. Number of cells per variant: pSuper/pEGFP-C1 (n = 35), ZBP1sh#1/pEGFP-C1 (n = 36), ZBP1sh#1/pEGFP-ZBP1* (n = 35), ZBP1sh#1/pEGFP-ZBP1*_S181A (n = 55), and ZBP1sh#1/pEGFP-ZBP1*_S181E (n = 47).