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. 2017 May 12;7:1880. doi: 10.1038/s41598-017-01971-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fz6 and Celsr1 exhibit uni-polar asymmetry as the mitotic spindle forms (A–E) immunostained ‘en-face’ frozen sections. Mitoses were oriented along the surrounding axis of planar polarity, dorsal is roughly to the top, anterior is left. Z-heat maps show Z-stack reconstructions of Celsr1 distribution during early mitosis (A) n = 2, asterisk labels uni-polar focal enrichment of Celsr1 (B) n > 3, asterisk labels uni-polar focal enrichment of Fz6 and Celsr1 at interface with neighbouring interphase cell, arrow labels Celsr1 enrichment in interphase neighbour (C) representative image, n = 3. Three early stage mitoses, labelled 1,2,3 together with a mitosis in cytokinesis (white dashed lines) whose plane of cell division is perpendicular to the axis of local planar polarity marked by cyto-N and Fz6. Yellow dots label neighbouring interphase cells with a long axis aligned with the axis of local planar polarity. Z-stack reconstructions of the nuclear mass for each early stage mitosis are shown underneath the right hand panel. (D) arrows label intracellular puncta co-expressing Fz6/rab11, n = 3. (E) TF is transferrin, n = 4, asterisk labels uni-polar Fz6 cell surface enrichment.