Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 May 12;7:1880. doi: 10.1038/s41598-017-01971-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Model of core protein dependent cell-contact mediated orientation of cell division in the mammalian skin. Taken together our data suggest that in wild-type the asymmetric cell surface cue which aligns cell division plane with neighbouring interphase long axis extent can be uni-polar (enriched at the interface between mitotic cell and the interphase neighbour) as shown in division 1 or bi-polar as shown in division 2,3. The asymmetric cue can be located ‘head-on’ with the mitotic cell as shown in division 1 and 2 or alongside the mitotic cell as shown in division 3. A: anterior, P: posterior, D; dorsal V; ventral. Blue arrows denote interphase long axis orientation, green arrows denote PCD orientation. In C. elegans cartoon, black box labels Wnt/Frizzled cell surface cue. Red boxes label Celsr1/Fz6 cell surface asymmetry. Black lines denote putative link between the cell contact cue and the mitotic spindle. Red dots denote Celsr1/Fz6-expressing intracellular vesicles. In core protein mutants Celsr1 planar polarised asymmetry during interphase diminishes as marked by red cell outlines.