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. 2017 May 10;7:1684. doi: 10.1038/s41598-017-01943-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene set enrichment analysis (GSEA) of c-Myc target genes. (a) C-Myc signature enrichment plots in Raji-luc + 500 nM JQ1, Brd4 f3, and Brd4 f9 cells versus DMSO-treated Raji-luc cells as a control for all three conditions. Plots were prepared using the SCHUHMACHER_MYC_TARGETS_UP²⁴ dataset (containing genes upregulated by c-Myc) available at the Molecular Signatures Database⁵¹. C-Myc upregulated target genes were enriched at the bottom of the ranked list of genes (ranking according to log2 fold-changes obtained from the previous DE analysis), indicating that genes upregulated by c-Myc tended to be repressed. (b) Table of selected c-Myc target gene sets^24–31 enriched in all three samples. n = number of genes in each set; NES = normalized enrichment score; FDR q-val = test of statistical significance. Negative NES indicates that genes in the respective target gene sets tended to be repressed.