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. 2017 May 12;7:1833. doi: 10.1038/s41598-017-01862-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of different treatment rates on equilibrium (A) prevalence of HCV infection; incidence per year of (B) chronic infection, (C) cured by successful treatment, (D) reinfection – which is always zero in this scenario because cured individuals change their behaviour to eliminate their reinfection risk; and (E) life-years gained; for three different network structures, for treatment rates varied from 0 to 30% per year, with behaviour-change post-treatment preventing reinfection. Points indicate median results and shading represents the 50% range (i.e. inter-quartile range) and 90% ranges of 100 model realizations of a network with 1000 PWID over a time period of 20 years (i.e. turnover of 50 people entering and exiting per year). For prevalence and incidence, the behaviour of the homogeneous-mixing model is also shown: as it is a deterministic model there is no range of uncertainty.