Fig. 6.

In vivo anti-inflammatory activity profile of in situ click chemistry hits. a, b Effective dose (ED₅₀) calculated at 3 and 5 h time after treatment of compound 18 (n = 4, ±s.e.m.) and 21 (n = 5, ±s.e.m.); c, e Control; d, f Images showing the in vivo effect at 3 h after treatment with 0.3 mg kg⁻¹ p.o. of compounds 18 (left paw) and 21 (right paw), respectively