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. 2017 May 10;7:1711. doi: 10.1038/s41598-017-01861-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dosing regimen scheme of busulfan in hematopoietic stem cell transplantation (HSCT) patients. Busulfan was administered once daily for 4 consecutive days and the area under the curve (AUC) was predicted from the pharmacokinetic (PK) modelling results. The solid line represents the predicted concentrations and open circles represent the observed concentrations at the sampling time (1, 2, and 4 h after the respective doses). According to the calculated AUC, the optimal dose was adjusted to meet the target AUC. ^†18,000–19,000 μg∙h/L/day, ^‡Sum of the AUC during 4 days (74,000 μg∙h/L).