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. 2017 May 10;7:1699. doi: 10.1038/s41598-017-01841-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Multi-pass TEM simulation of protein structures. (a) Shows the ribbon diagram and (b) shows the projected potential of MARV VP35. (c) Shows simulated multi-pass phase TEM images for 300 keV electrons, calculated at three respective levels of effective dose, which are shown on the right. Note that the incoming dose for each panel is roughly m-fold lower than the effective dose, as explained in the text. The white circles indicate figures of similar SNR (see text). The red line indicates the typical critical dose (~20 e⁻/Å²) for biological specimens²³. (d–f) Show the results for two different projections of HIV–1 Gag. All scalebars are 2 nm, the colorscale for (c) and (f) is in units of standard deviations from the mean intensity of each image.