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. 2017 May 10;7:1698. doi: 10.1038/s41598-017-01730-3

Figure 5.

Figure 5

Glycation causes systemic dysmetabolism and impairs skeletal muscle insulin signaling in high-fat diet-fed rats. Circulating levels of adiponectin (A), FFAs (B) and insulin (C) were quantified by ELISA. Glucose intolerance was evaluated through the area under the curve of an IPGTT (D). Skeletal muscle insulin signalling was evaluated through WB quantification of activated and total forms of IR (E) and Akt (F) as well as GLUT4 transporter (G). Ct - Wistar 12 m; MG - Wistar + MG supplementation; HFD - HF diet-fed Wistar; HFDMG - HF diet-fed Wistar + MG supplementation; GK - Goto-Kakizaki 12 m. Bars represent means ± SEM, n = 6–8. * vs Ct; # vs MG; $ vs HFD; & vs HFDMG; 1 symbol p < 0.05; 2 symbols p < 0.01; 3 symbols p < 0.001.