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. 2017 May 10;7:1652. doi: 10.1038/s41598-017-01520-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The ultrastructure of the tuft cell in the third dimension. (A) Schematic overview of the intestinal tuft cell. All data in panels are oriented from top-lumen to bottom-basal lamina. (B) An SBEM micrograph revealing a tuft cell in the mouse distal small intestine (yellow). Cytoplasmic spinules (arrows) projecting into adjacent cells and vesicles beneath the microvilli are evident at this resolution (5 nm/pixel). (C) Morphometrical assessment of tuft cell microvilli. Measurements are an average of 30 individual microvilli from three different cells in each group. (D) Volume rendering of 500 consecutive SBEM micrographs shows the complete 3D ultrastructure of tuft cell in the third dimension, including microvilli (orange), basal process, and cytospinules (arrows). See also Video 1. Bars = 1 µm.