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. 2017 May 11;7:1787. doi: 10.1038/s41598-017-01973-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PSC display an activated phenotype in culture and in a murine model of CP. PaSC were treated with (a) 10 μM all-trans retinoic acid (ATRA) or (b) vehicle control for 48 hours and stained for Oil-Red O. Cells were analyzed by light microscopy at 40X magnification. (c) Untreated PaSC were stained for α-SMA (green) by fluorescent microscopy following 48 hours of incubation (DAPI counterstain, 40X magnification). (d) Formalin fixed paraffin embedded (FFPE) pancreatic tissue from mice with caerulein-induced pancreatitis after (d) 1 week and (e) 5 weeks of treatment were stained for α-SMA (20X magnification). Representative images from n = 5 mice per group.