Table 2.
Risk of cardiovascular events and mortality in patients with diabetes mellitus and renal impairment for the TZDs versus control groups.
| Outcomes | No. of Study | Events/Total | RR (95%CI) | P Value | I2 | |
|---|---|---|---|---|---|---|
| TZDs | Control | |||||
| Heart failure | 5 RCTs | 2/120 | 4/113 | 0.64 (0.15, 2.66) | 0.54 | 0% |
| Angina | 3 RCTs | 2/84 | 1/84 | 1.45 (0.23, 8.95) | 0.69 | 0% |
| MI | 2 RCTs | 0/45 | 0/46 | — | — | — |
| Cardiovascular Mortality | 1 RCT | 0/26 | 1/26 | 0.33 (0.01, 7.82) | 0.50 | — |
| 1 cohort study | 29/177 | 273/2050 | 1.23 (0.87, 1.75) | 0.25 | — | |
| All-cause Mortality | 5 RCTs | 1/323 | 4/555 | 0.40 (0.08, 2.01) | 0.27 | 0% |
| 2 cohort studies | 74/407 | 714/2716 | 0.78 (0.38, 1.59) | 0.62 | 85% | |