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. 2017 May 12;7:1862. doi: 10.1038/s41598-017-01819-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell-type distribution of PEI-FITCsiRNA in mouse brain following intranasal administration. Representative images of brain sections immunolabeled with antibodies to the microglial marker, Iba1 (left panel), astrocyte marker, GFAP (middle panel), and neuronal marker, Map2 (right panel), in red for (A) PBS treatment, and PEI-FITCsiRNA (indicated by green fluorescence) administration for (B) 4 hours and (C) 24 hours. DAPI (blue) staining indicates cell nuclei at 63X magnification. (D) The other half of brain tissues was used to detect the indicated cytokines and chemokines by ELISA after 4 and 24 hours. Values were determined from standard curves and are presented as the mean ± the standard error of the mean (S.E.M.) of three independent experiments.