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. 2017 May 11;7:1750. doi: 10.1038/s41598-017-01947-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Detailed view of disc assembly. The grey layers are PMMA, the green layers are PSA. (B) Image of fully assembled disc with integrated electrodes (cropped to view one section). Chamber (i–iv) are preloaded with (i) target miRNA strands, (ii) PBS wash step, (iii) PtNP labelled probe miRNA strands, (iv) PBS wash step/electrolyte. Chamber (v) is the electrode chamber with ITO reference, gold working electrode and gold counter electrode. Chamber (vi) is the waste chamber, with an overflow system implemented at (vii) and (vii); these contain DF tabs. (ix) shows the siphon between the electrode chamber and the waste chamber. Labelled at (x) are the vents for the electrode chamber. (C) Hybridisation of miRNA strands on surface of working electrode inside chamber (v).