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. 2017 May 10;7:1653. doi: 10.1038/s41598-017-01966-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AI and splice site mutations. (a) Barplots show the relative proportion of sig-pos-AFD (blue), sig-neg-AFD (red), and the other mutations (gray) for splice site mutations across five tumor types. (b) The sig-pos-AFD ratio (blue) and the other ratio (purple) are shown at the canonical 5′ splice site (GT) and 3′ splice site (AG). (c) The frequency of the splice site mutations with the sig-pos-AFD are shown for genes with the ≥ 2 sig-pos-AFD events in the given tumor type.