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. 2017 May 11;7:1728. doi: 10.1038/s41598-017-01572-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SHP-1 phosphatase is associated with liver fibrosis. (a) The structure of sorafenib and its derivative SC-43. (b) SHP-1 located primarily in areas with α-SMA-expressed activated HSCs and significant fibrosis by sirius red staining of the CCl₄-induced fibrosis mouse liver. (c) SHP-1 overexpression in fibrotic areas of patients with CHB with advanced fibrosis, graded by the Metavir scores (F0–F4). The SHP-1 located in sirius red-positive fibrotic areas. (d) SHP-1 expression according to Metavir score. (e) SHP-1 expression positively correlated with APRI. (f) SHP-1 colocalized with α-SMA-expressed activated HSCs in human liver. Scale bar: 200 μm.