Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 May 11;7:1728. doi: 10.1038/s41598-017-01572-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

SC-43 treatment induces apoptosis of hepatic stellate cells. (a) Dose-escalation effects of SC-43 and sorafenib administered for 24 h on the cell viability of LX2 and HSC-T6 cells. (b) Dose-escalation and time-dependent effects of SC-43 administration for 24 h or 48 h on the cell viability of primary mouse HSCs. (c) Dose-escalation effects of SC-43 and sorafenib administration for 24 h on the apoptosis of LX2 and HSC-T6 cells. (d) SC-43 induced LX2 and HSC-T6 apoptosis by increasing the cleaved PARP fragments. (e) The SC-43-induced downregulation of the TGF-β pathway in LX2 cells. (f) The SC-43-induced downregulation of p-PDGFR and p-Akt in the PDGF pathway in LX2 and HSC-T6 cells. Columns: mean and bars: standard error (n = 3–4). *P < 0.05, **P < 0.01, and ***P < 0.001.