Table 2. Summary statistics for genetic data CTCAE grading for COMT, TPMT and ACYP2 CTCAE criteria using worse ear in cases of asymmetric hearing loss.

COMT		Grade 0 (n=26)	Grade 1 (n=8)		Grade 2 (n=41)		Grade 3 (n=35)	Grade 4 (n=6)
rs9332377	CC	18 (22.5%)	4 (5%)		28 (35%)		27 (33.8%)	3 (3.8%)
	CT	7 (21.1%)	3 (9.4%)		12 (37.5%)		7 (21.9%)	3 (9.4%)
	TT	1 (25%)	1 (25%)		1 (25%)		1 (25%)	0 (0%)
rs4646316	CC	18 (26.1%)	4 (5.8%)		24 (34.8%)		19 (27.5%)	4 (5.8%)
	CT	6 (14.3%)	4 (9.5%)		14 (33.3%)		16 (38.1%)	2 (4.8%)
	TT	1 (33.3%)	0 (0%)		2 (66.7%)		0 (0%)	0 (0%)
TPMT
rs12201199	AA	18 (19.1%)	7 (7.4%)		33 (35.1%)		30 (31.9%)	6 (6.4%)
	AT	7 (33.3%)	1 (4.8%)		8 (38.1%)		5 (23.8%)	0 (0%)
	TT	1(100%)	0 (0%)		0 (0%)		0 (0%)	0 (0%)
rs1142345	TT	22 (22%)	7 (7%)		34 (34%)		31 (31%)	6 (6%)
	TC	3 (21.4%)	1 (7.1%)		6 (42.9%)		4 (28.6%)	0 (0%)
	CC	1(100%)	0 (0%)		0 (0%)		0 (0%)	0 (0%)
rs1800460	CC	24 (22.6%)	7 (6.6%)		37 (34.9%)		32 (30.2%)	6 (5.7%)
	CT	1 (11.1%)	1 (11.1%)		4 (44.4%)		3 (33.3%)	0 (0%)
	TT	1(100%)	0 (0%)		0 (0%)		0 (0%)	0 (0%)
ACYP2
		Grade 0 (n=31)	Grade 1a (n=17)	Grade 1b (n=15)	Grade 2a (n=5)	Grade2b (n=10)	Grade 3 (n=32)	Grade 4 (n=5)
rs1872328	GG	29 (27.4%)	16 (15.1%)	10 (9.4%)	5 (4.7%)	10 (9.4%)	31 (29.2%)	5 (4.7%)
	GA	1 (16.7%)	1 (16.7%)	4 (66.7%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)
	AA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)