Table 3. Multivariable regression analysis of the association between COMT and TPMT polymorphisms and cisplatin-induced ototoxicity using CTCAE grading as an ordinal outcome.
| Estimate (SE) | Overall P-value | Bonferroni corrected P- value | |
|---|---|---|---|
| COMT rs9332377 (CC) | |||
| Grade 1 vs Grade 0: | 1.03 (0.72) | ||
| Grade 2 vs Grade 0: | 0.19 (0.53) | 0.30 | 1.00 |
| Grade 3 vs Grade 0: | -0.54 (0.60) | ||
| Grade 4 vs Grade 0: | 0.47 (0.76) | ||
| COMT rs4646316 (CC) | |||
| Grade 1 vs Grade 0: | 0.52 (0.77) | ||
| Grade 2 vs Grade 0: | -0.10 (0.56) | 0.93 | 1.00 |
| Grade 3 vs Grade 0: | 0.079 (0.59) | ||
| Grade 4 vs Grade 0: | -0.24 (0.94) | ||
| TPMT rs12201199 (AA) | |||
| Grade 1 vs Grade 0: | -1.07 (1.12) | ||
| Grade 2 vs Grade 0: | -0.92 (0.65) | 0.068 | 0.34 |
| Grade 3 vs Grade 0: | -1.66 (0.78) | ||
| Grade 4 vs Grade 0: | -17.6 (2940) | ||
| TPMT rs1142345 (TT) | |||
| Grade 1 vs Grade 0: | -0.47 (1.10) | ||
| Grade 2 vs Grade 0: | -0.43 (0.70) | 0.55 | 1.00 |
| Grade 3 vs Grade 0: | -0.72 (0.83) | ||
| Grade 4 vs Grade 0: | -16.9 (3450) | ||
| TPMT rs1800460 (CC) | |||
| Grade 1 vs Grade 0: | -0.041 (1.10) | ||
| Grade 2 vs Grade 0: | -0.13 (0.78) | 0.83 | 1.00 |
| Grade 3 vs Grade 0: | -0.23 (0.96) | ||
| Grade 4 vs Grade 0: | -16.4 (3990) | ||
Analysis undertaken using worse ear grade (in cases of asymmetric hearing loss)