. Author manuscript; available in PMC: 2018 Jun 1.

Published in final edited form as: Pharmacogenet Genomics. 2017 Jun;27(6):213–222. doi: 10.1097/FPC.0000000000000281

Table 6. Key information about the papers included in the systematic review.

	Number of patients	Study design	Ethnicity	SNP(s) investigated	Outcomes and Definitions

Hagleitner et al 2014
Dutch cohort	110	Retrospective	Dutch	TPMT rs12201199, rs1800460 and rs1142345; COMT rs4646316 and rs9332377	Hearing loss, CTCAE version 3.0 (Grade 0 vs 2-4) and SIOP Boston ototoxicity scale (Grade 0 vs 2-4). Unclear whether worse or better ear.
Spanish cohort	38	Retrospective	European

Lanvers-Kaminsky et al 2014
	63	Retrospective	unclear	TPMT rs12201199 and COMT rs9332377	Hearing loss, Muenster classification (Grade 0 vs 2-4).

Pussegoda et al 2013
	155	Case-control	80% Caucasian 20% other	TPMT rs12201199, rs1800460 and rs1142345; COMT rs4646316 and rs9332377	Hearing loss, CTCAE version 3 criteria (Grade 0 vs 2-4). Unclear whether worse or better ear.

Ross et al 2009
Discovery cohort	53	Case-control	85% European 15% Non-European	Genotyped for 1,949 SNPs using customized genotyping assay designed to capture the genetic variation of 220 key drug metabolism genes	Ototoxicity, CTCAE version 3 criteria (Grade 2-4 vs 0). Unclear whether worse or better ear.
Replication cohort	109	Case-control	85% European 15% Non-European

Yang et al 2013
Cohort A	213	Retrospective	79% White 21% non-White	TPMT rs1800462, rs12201199, rs1800460 and rs1142345; COMT rs4818, rs4646316 and rs9332377	Hearing loss, worse ear, CTCAE version 3 criteria (Grade 0 vs >0, Grade 0 vs 2-4 and analysed as ordinal variable) and Chang criteria, (Grade 0 vs Grade>0; Grade <2a vs ≥2a and analysed as ordinal variable)
Cohort B	14	Retrospective	61% White 39% non-White

Xu et al 2015
Discovery cohort	238	Retrospective	66% European American, 34% Other.	GWAS 2,602,667 SNPs on Illumina HumanOmni2.5+HumanExome BeadChip.	Time to hearing loss (worse ear), classified as Chang score>0 and analysed as ordinal variable.
Validation cohort	68	Retrospective	Unclear	ACYP2 rs1872328; rs7604464.	Time to hearing loss (worse ear), classified as Chang score>0

Vos et al 2016
	156	Retrospective	99% European	ACYP2 SNP rs1872328	Hearing loss, Chang score, Grade 0 vs Grade>0