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. 2017 Apr 8;22(3):e324–e332. doi: 10.4317/medoral.21901

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Copyright: © 2017 Medicina Oral S.L.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Histological features of ameloblastic carcinoma, a. Epithelial islands with artefactual empty central spaces showing a follicular pattern, resembling an ameloblastic epithelium with columnar peripheral cells. The stroma is highly collagenized (H&E, 400X), b. Sheets of malignant epithelial cells showing a peripheral layer formed by columnar cells, with ameloblastic characteristics, including reversal nuclear polarization. Cellular pleomorphism and atypical mitosis are evident (H&E, 400X), c. Sheets of malignant epithelial cells showing a central area of necrosis (H&E, 200X). d, Islands of well-defined malignant epithelium, with flattened peripheral cells separated by collagenized stroma. The islands are frequently separated from the adjacent stroma, suggesting a poor adherence of epithelium/stroma adherence interface (H&E, 200X).