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. 2017 Apr 8;22(3):e324–e332. doi: 10.4317/medoral.21901

Figure 4.

Figure 4

Main immunohistochemical features in ameloblastic carcinoma: a. Epithelial cells showing strong and high expression of Ki-67 in most of the cells (200X), b. Nuclear expression of p53 in AC, positive cells are evident, but the intensity of the staining is weak (200X), c. p63 immunostaining in ameloblastic carcinoma, with most of the nuclei strongly positive (200X), d. Strong and homogenous expression of CK5 in AC, both in the central and peripheral cells of the epithelial islands, with loss of expression in focal areas (200X), e. Neoplastic islands illustrating strong expression for CK14 in most cells, but loss of staining or weak expression in focal regions (200X), f. CK19 staining in ameloblastic carcinoma, showing strongly positive cells permeated by negative cells in both peripheral and central areas (200X), g. epithelial malignant sheet showing most cells with strong positivity for CD138 (400X), h. Case of AC strongly expressing E-cadherin in most of the cells; nevertheless, expression was variable in most cases, and some were negative (200X), i. Case of AC showing strong expression of β-catenin. In most cases it was weakly positive or negative (200X).