Table 6. AChE activities and glucose levels in the brain of diabetic rats and after treatment with NSO, antidiabetic drugs, combination therapy and I-OMeAG538-injection.
| Groups | AChE (μmol/min/mg protein) | Glucose (mg/mg protein) |
|---|---|---|
| Control | 93.60 ± 1.34# | 0.78 ± 0.04# |
| D | 306 ± 9.60* | 0.13 ± 0.02* |
| DMSO | 255 ± 6.98* | 0.25 ± 0.01* |
| NSO | 68.8 ± 5.20*# | 0.71 ± 0.09# |
| MT | 116 ± 4.90*# | 0.59 ± 0.01*# |
| NSO-MT | 166 ± 5.10*# | 0.74 ± 0.04# |
| GI | 110 ± 2.90*# | 0.44 ± 0.02*# |
| NSO-GI | 131 ± 1.40*# | 0.46 ± 0.01*# |
| D-NSO | 81 ± 3.30*# | 0.74 ± 0.09# |
| D-MT | 100 ± 6.60# | 0.45 ± 0.07*# |
| D-GI | 146 ± 6.87*# | 0.52 ± 0.01*# |
| D-NSO-MT | 122 ± 4.90*# | 0.50 ± 0.09*# |
| D-NSO-GI | 123 ± 4.70*# | 0.49 ± 0.01*# |
| IOMe | 227 ± 4.30* | 0.29 ± 0.05* |
| IOMe-NSO | 149 ± 5.20*# | 0.51 ± 0.03*# |
| D-IOMe | 265 ± 6.70* | 0.19 ± 0.06* |
| D-IOMe-NSO | 121 ± 4.80*# | 0.45 ± 0.09*# |
Values are expressed as mean± SE (n = 8). Significance:
*p<0.05 (compared to control) and
#p<0.05 (compared to diabetics).