Table 7. Alteration in AGEs levels in brain and in serum of diabetic rats after treatment with NSO, antidiabetic drugs, combination therapy and I-OMeAG538.
| Groups | Brain AGEs (U/mg protein) | Serum AGEs (U/ml) |
|---|---|---|
| Control | 0.10 ± 0.01# | 2.00 ± 0.09# |
| D | 1.32 ± 0.07* | 25.20 ± 0.19* |
| DMSO | 0.49 ± 0.06*# | 11.70 ± 0.1*# |
| NSO | 0.07 ± 0.01# | 1.30 ± 0.06*# |
| MT | 0.082 ± 0.01# | 2.20 ± 0.04# |
| NSO-MT | 0.068 ± 0.02# | 1.80 ± 0.02# |
| GI | 0.18 ± 0.05# | 2.10 ± 0.05# |
| NSO-GI | 0.11 ± 0.03# | 1.94 ± 0.09# |
| D-NSO | 0.094 ± 0.01# | 0.95 ± 0.03*# |
| D-MT | 1.68 ± 0.04*# | 3.00 ± 0.04*# |
| D-GI | 2.26 ± 0.05*# | 5.60 ± 0.04*# |
| D-NSO-MT | 0.08 ± 0.01# | 1.20 ± 0.06*# |
| D-NSO-GI | 0.13 ± 0.03# | 3.80 ± 0.07*# |
| IOMe | 0.79 ± 0.04*# | 19.20 ± 0.13* |
| IOMe-NSO | 0.26 ± 0.03*# | 3.30 ± 0.09*# |
| D-IOMe | 1.46 ± 0.06* | 28.70 ± 0.17* |
| D-IOMe-NSO | 0.30 ± 0.03*# | 5.60 ± 0.04*# |
Values are expressed as mean± SE (n = 8). Significance:
*p<0.05 (compared to control) and
#p<0.05 (compared to diabetics).