Fig 2. Frequencies of memory CD4⁺ and CD8⁺ T cells responsive (CD69⁺) to M. leprae cell sonicates in household contacts of multibacillary leprosy patients (HCMB).

Frequencies of central and effector memory CD4⁺(A) and CD8⁺(C) T cells expressing CD69 in response to 6-hour in vitro stimulation with M. leprae cell sonicate at T0 and T1. Each black circle represents one HCMB. The red lines represent the median values at the different time points. Individual lymphocyte frequencies of central memory CD4⁺ CD69⁺ T cells (B) and central memory CD8⁺ CD69⁺ T cells (D) after index case treatment and BCG vaccination of the HCMB. Each bar represents a single contact identified by the number under the bar. Orange bars represent contacts who received the first BCG dose at T0; red bars represent the HCMB who received a second BCG dose at T0; and the blue bars represent the HCMB who were not BCG vaccinated at T0. n = 12. * p<0.05.