Simulation I: Five classes of tree topologies were considered: monoclonal (MC), polyclonal-low (PL), polyclonal-middle (PM), polyclonal-high (PH), and mutator-phenotype (MT). Simulation II: Three classes of edge lengths of the tree are considered: trunk accumulation (TR), branched accumulation (BR), and balanced accumulation (BL). Simulation III: Nine classes of trees are considered: polyclonal-low trunk accumulation (PL-TR), polyclonal-low balanced accumulation (PL-BL), polyclonal-low branch accumulation (PL-BR), polyclonal-middle trunk-accumulation (PM-TR), polyclonal-middle balanced-accumulation (PM-BL), polyclonal-middle branch-accumulation (PM-BR), polyclonal-high trunk accumulation (PH-TR), polyclonal-high balanced accumulation (PH-BL), and polyclonal-high branch accumulation (PH-BR)