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. Author manuscript; available in PMC: 2017 May 15.
Published in final edited form as: Mol Immunol. 2016 May 20;75:28–37. doi: 10.1016/j.molimm.2016.05.009

Fig. 6. Molecular mimicry of anti-BAFF VNARs.

Fig. 6

A. CDR1 and CDR3 sequences of the 13 blocking clones. DXL motifs are highlighted in the CDR3. B. Molecular modeling of the anti-BAFF clone A07 in complex with a BAFF trimer. The BAFF trimer is shown space filled in different shades of grey and the modeled VNAR is shown as a ribbon diagram with the CDR1 in green and the CDR3 in orange. The residues of the DXL are shown in red. C. Superimposition of the A07CDR3 and a BAFF receptor interacting loop (mini BR3 peptide) binding to a BAFF monomer. mini BR3 is shown as a blue ribbon with the DXL motif shown as a stick diagram illustrating its close alignment with the DXL motif of the VNAR.