Hematoxylin and eosin staining shows HCC arising in the livers from two different pigs (original magnifications, ×100 and ×400). Immunohistochemical staining shows the expression of GHR, JAK2, STAT3, STAT5, and IGF-IR in the HCC developed in our model. In addition, the expression of the phosphorylated/activated forms of these proteins including pJAK2, pSTAT3, pSTAT5, and pIGF-IR in HCC is also pronounced (original magnification, ×400).