Figure 8. DSF-Cu disrupts formation of IBC tumor emboli under in vitro simulated growth conditions.

A. Representative images (10 x – scale bar = 200 microns) of SUM149 cells grown under tumor emboli conditions for 1-4 days and treated with 10 μM copper (Cu), 100 nM disulfiram (DSF) or DSF-Cu. B. Percent of spheroid number relative to untreated for SUM149 cells grown for 4-5 days [#P<0.005 comparisons made between treatment and untreated].