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. 2016 Nov 4;8(16):25897–25914. doi: 10.18632/oncotarget.13071

Figure 4. Rb1 and its metabolite compound K reduce chemoresistance of CSCs.

Figure 4

A. SKOV-3 or HEYA8 CSCs or B. CSCs isolated from primary ovarian tumors were untreated or treated with cisplatin (CDDP; 50 μM) or paclitaxel (PTX; 100 nM) alone or in combination with Rb1 (250 nM) or compound K (CK) (125 nM) for 24 h. The number of tumor spheres generated were photographed (left) and counted (right). Bar, 50 μm. In parallel experiments, cell viability was determined by MTT assay. The absorbance of wells not exposed to Rb1 or CK treatment was arbitrarily set as 1, and cell growth after Rb1 or CK treatment was expressed as the fold changes compared to the control. Experiments were repeated three times, and data are shown as mean ± SD. *, P < 0.05 vs control.