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. 2017 Feb 16;8(16):26129–26141. doi: 10.18632/oncotarget.15387

Figure 5. Microarray results of ZNF521 depletion in THP-1 cells.

Figure 5

(A) Hierarchical clustering analysis of differently gene expression profiles associated with transduced THP-1 cells with ZNF521 shRNA (ZNF004) or control shScram after 4 days of transduction. Each column represents a sample and each row represent a gene. Relative levels of gene expression are depicted with a color scale where red represents the highest level of expression and green represents the lowest level. (B–E) GSEA plot showing gene expression signature of (B) negative enrichment of cell cycle signature, (C) negative enrichment of downregulated genes in myeloid cell development signature, (D) positive enrichment of downregulated genes in HSCs signature and (E) negative enrichment of embryonic stem cell core signature. (F, G) GSEA plot showing negative enrichment of MLL signature up-regulated genes in pediatric AML. (H–K) GSEA showing enrichment of upregulated genes in HOXA9 up-regulated (H) and down-regulated (I) signatures in HOXA9 knockdown cells, (J) positive enrichment of HOXA9 targets up-regulated and (K) negative enrichment of HOXA9 targets down-regulated in hematopoietic stem cells. The normalization enrichment score (NES) and the false discovery rate (FDR) values are indicated in each panel. Red and blue color bars indicated the positive and negative enrichment, respectively.